Chapter 18. Stimulus-Transcription Coupling in the Nervous System: The Zinc Finger Protein Egr–1

  1. Prof. Dr. Gerald Thiel
  1. Oliver G. Rössler,
  2. Luisa Stefano,
  3. Inge Bauer and
  4. Gerald Thiel

Published Online: 22 MAY 2006

DOI: 10.1002/3527608036.ch18

Transcription Factors in the Nervous System: Development, Brain Function, and Diseases

Transcription Factors in the Nervous System: Development, Brain Function, and Diseases

How to Cite

Rössler, O. G., Stefano, L., Bauer, I. and Thiel, G. (2005) Stimulus-Transcription Coupling in the Nervous System: The Zinc Finger Protein Egr–1, in Transcription Factors in the Nervous System: Development, Brain Function, and Diseases (ed G. Thiel), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527608036.ch18

Editor Information

  1. Department of Medical Biochemistry and Molecular Biology, University of Saarland Medical Center, Building 44, 66421 Homburg, Germany

Author Information

  1. Department of Medical Biochemistry and Molecular Biology, University of Saarland Medical Center, Building 44, 66421 Homburg, Germany

Publication History

  1. Published Online: 22 MAY 2006
  2. Published Print: 16 DEC 2005

ISBN Information

Print ISBN: 9783527312856

Online ISBN: 9783527608034

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Keywords:

  • transcription factors;
  • brain function;
  • stimulus-transcription coupling in nervous system;
  • zinc finger protein Egr–1;
  • modular structure of Egr–1;
  • intracellular signaling cascades converging at Egr–1 gene;
  • Egr–1 promoter;
  • Egr–1–deficient mice;
  • Egr–1 regulates synaptic plasticity;
  • Egr–1 a “pro-apoptotic protein” for neurons

Summary

This chapter contains sections titled:

  • Abstract

  • Introduction

  • Modular Structure of Egr–1

  • Intracellular Signaling Cascades Converging at the Egr–1 Gene

  • The Egr–1 Promoter

  • Lessons from Egr–1–Deficient Mice

  • Egr–1 Regulates Synaptic Plasticity in the Nervous System

  • Correlation Between Proliferation of Astrocytes and Egr–1 Biosynthesis

  • Egr–1: A “Pro-apoptotic Protein” for Neurons?

  • Conclusions and Future Prospects

  • Acknowledgments

  • Abbreviations