Chapter 19. The Presenilin/γ-Secretase Complex Regulates Production of Transcriptional Factors: Effects of FAD Mutations

  1. Prof. Dr. Gerald Thiel
  1. Nikolaos K. Robakis1 and
  2. Philippe Marambaud2

Published Online: 22 MAY 2006

DOI: 10.1002/3527608036.ch19

Transcription Factors in the Nervous System: Development, Brain Function, and Diseases

Transcription Factors in the Nervous System: Development, Brain Function, and Diseases

How to Cite

Robakis, N. K. and Marambaud, P. (2005) The Presenilin/γ-Secretase Complex Regulates Production of Transcriptional Factors: Effects of FAD Mutations, in Transcription Factors in the Nervous System: Development, Brain Function, and Diseases (ed G. Thiel), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527608036.ch19

Editor Information

  1. Department of Medical Biochemistry and Molecular Biology, University of Saarland Medical Center, Building 44, 66421 Homburg, Germany

Author Information

  1. 1

    Mount Sinai School of Medicine, New York University, One Gustave Levy Place, Box 1229, New York, New York 10029, USA

  2. 2

    Department of Pathology, Forchheimer Building, Room 526, Albert Einstein College of Medicine, 1300 Morris Park Avenue Bronx, New York, New York 10461, USA

Publication History

  1. Published Online: 22 MAY 2006
  2. Published Print: 16 DEC 2005

ISBN Information

Print ISBN: 9783527312856

Online ISBN: 9783527608034

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Keywords:

  • transcription factors;
  • neuronal diseases;
  • presenilin/γ-secretase complex;
  • regulates production of transcriptional factors;
  • effects of FAD mutations;
  • processing of APP and FAD;
  • Notch1 ICD (NICD) mediates transcriptional and developmental functions;
  • Notch1 receptor;
  • transcriptional function of APP ICD (AICD);
  • PS1 mediated transcription;
  • β-catenin-mediated transcription;
  • PS1 a regulator of cadherin-dependent cell-cell adhesion;
  • signal transduction

Summary

This chapter contains sections titled:

  • Abstract

  • Introduction

  • Processing of APP and FAD

  • The Presenilins

  • The Notch1 ICD (NICD) Mediates Transcriptional and Developmental Functions Associated with Notch1 Receptor

  • Transcriptional Function of the APP ICD (AICD)

  • PS1 and β-Catenin-Mediated Transcription

  • PS1 is a Critical Regulator of Cadherin-Dependent Cell-Cell Adhesion and Signal Transduction

  • Conclusions

  • Abbreviations