Chapter 2. The Role of Pax6 in the Nervous System during Development and in Adulthood: Master Control Regulator or Modular Function?

  1. Prof. Dr. Gerald Thiel
  1. Nicole Haubst1,
  2. Jack Favor2 and
  3. Magdalena Götz1

Published Online: 22 MAY 2006

DOI: 10.1002/3527608036.ch2

Transcription Factors in the Nervous System: Development, Brain Function, and Diseases

Transcription Factors in the Nervous System: Development, Brain Function, and Diseases

How to Cite

Haubst, N., Favor, J. and Götz, M. (2005) The Role of Pax6 in the Nervous System during Development and in Adulthood: Master Control Regulator or Modular Function?, in Transcription Factors in the Nervous System: Development, Brain Function, and Diseases (ed G. Thiel), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527608036.ch2

Editor Information

  1. Department of Medical Biochemistry and Molecular Biology, University of Saarland Medical Center, Building 44, 66421 Homburg, Germany

Author Information

  1. 1

    Institute of Stem Cell Research, GSF National Research Center for Environment and Health, Ingolstädter Landstr.1, 85764 Neuherberg/Munich, Germany

  2. 2

    Institute of Human Genetics, GSF National Research Center for Environment and Health, Ingolstädter Landstr. 1, 85764 Neuherberg/Munich, Germany

Publication History

  1. Published Online: 22 MAY 2006
  2. Published Print: 16 DEC 2005

ISBN Information

Print ISBN: 9783527312856

Online ISBN: 9783527608034

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Keywords:

  • transcription factors;
  • neural development;
  • role of Pax6 in nervous system;
  • during development;
  • in adulthood;
  • molecular features of Pax6;
  • function of Pax6 in adult brain;
  • mechanisms of Pax6 function

Summary

This chapter contains sections titled:

  • Abstract

  • Introduction

  • Molecular Features of Pax6

    • The Paired Domain

    • The Paired-Type Homeodomain

    • Different Pax6 Isoforms

    • Protein-Protein Interactions

    • Post-Translational Modifications of Pax6

  • Function of Pax6 in Development

    • Function of Pax6 in the Developing Eye

    • Function of Pax6 in the Developing Brain

      • Telencephalon

      • Diencephalon

      • Cerebellum

      • Spinal Cord

  • Function of Pax6 in the Adult Brain

  • Mechanisms of Pax6 Function

  • Conclusions and Outlook

  • Abbreviations