Chapter 20. Transcriptional Abnormalities in Huntington's Disease

  1. Prof. Dr. Gerald Thiel
  1. Dimitri Krainc

Published Online: 22 MAY 2006

DOI: 10.1002/3527608036.ch20

Transcription Factors in the Nervous System: Development, Brain Function, and Diseases

Transcription Factors in the Nervous System: Development, Brain Function, and Diseases

How to Cite

Krainc, D. (2005) Transcriptional Abnormalities in Huntington's Disease, in Transcription Factors in the Nervous System: Development, Brain Function, and Diseases (ed G. Thiel), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527608036.ch20

Editor Information

  1. Department of Medical Biochemistry and Molecular Biology, University of Saarland Medical Center, Building 44, 66421 Homburg, Germany

Author Information

  1. Department of Neurology, Massachusetts General Hospital, Harvard Medical School, MassGeneral Institute for Neurodegeneration, 114 16th Street, Charlestown, Massachusetts 02129, USA

Publication History

  1. Published Online: 22 MAY 2006
  2. Published Print: 16 DEC 2005

ISBN Information

Print ISBN: 9783527312856

Online ISBN: 9783527608034

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Keywords:

  • transcription factors;
  • neuronal diseases;
  • transcriptional abnormalities in Huntington's Disease;
  • mutant Huntingtin;
  • disrupts Sp1–TAF4 transcriptional pathway;
  • deregulation of CRE-dependent transcription in HD

Summary

This chapter contains sections titled:

  • Abstract

  • Introduction

  • Mutant Huntingtin Interferes with Specific Components of General Transcriptional Machinery

  • Mutant Huntingtin Disrupts Sp1–TAF4 Transcriptional Pathway

  • Deregulation of CRE-Dependent Transcription in HD

  • Summary

  • Abbreviations

  • Acknowledgments