Chapter 6. RE–1 Silencing Transcription Factor (REST): Regulation of Neuronal Gene Expression via Modification of the Chromatin Structure

  1. Prof. Dr. Gerald Thiel
  1. Gerald Thiel and
  2. Mathias Hohl

Published Online: 22 MAY 2006

DOI: 10.1002/3527608036.ch6

Transcription Factors in the Nervous System: Development, Brain Function, and Diseases

Transcription Factors in the Nervous System: Development, Brain Function, and Diseases

How to Cite

Thiel, G. and Hohl, M. (2005) RE–1 Silencing Transcription Factor (REST): Regulation of Neuronal Gene Expression via Modification of the Chromatin Structure, in Transcription Factors in the Nervous System: Development, Brain Function, and Diseases (ed G. Thiel), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527608036.ch6

Editor Information

  1. Department of Medical Biochemistry and Molecular Biology, University of Saarland Medical Center, Building 44, 66421 Homburg, Germany

Author Information

  1. Department of Medical Biochemistry and Molecular Biology, University of Saarland Medical Center, Building 44, 66421 Homburg, Germany

Publication History

  1. Published Online: 22 MAY 2006
  2. Published Print: 16 DEC 2005

ISBN Information

Print ISBN: 9783527312856

Online ISBN: 9783527608034

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Keywords:

  • transcription factors;
  • neural development;
  • RE-1 silencing transcription factor (REST);
  • regulation of neuronal gene expression;
  • modification of chromatin structure;
  • tissue-specific gene expression;
  • modular structure of REST;
  • biological activity of REST

Summary

This chapter contains sections titled:

  • Abstract

  • Tissue-Specific Gene Expression: The Molecular Basis for the Function of a Multicellular Organism

  • Modular Structure of REST

  • Biological Activity of REST

  • Mechanism of Transcriptional Repression by REST: Modulation of the Chromatin Structure

  • Lessons from the REST Knockout Mouse

  • Cell Type-Specific Regulation of REST Target Genes

  • The Role of REST in the Differentiation of Neural Stem Cells

  • Involvement of REST in Brain Dysfunction and Disease

  • Conclusion and Prospects

  • Acknowledgments

  • Abbreviations