Chapter 7. Roles of Tlx1 and Tlx3 and Neuronal Activity in Controlling Glutamatergic over GABAergic Cell Fates

  1. Prof. Dr. Gerald Thiel
  1. Qiufu Ma1 and
  2. Le-ping Cheng2

Published Online: 22 MAY 2006

DOI: 10.1002/3527608036.ch7

Transcription Factors in the Nervous System: Development, Brain Function, and Diseases

Transcription Factors in the Nervous System: Development, Brain Function, and Diseases

How to Cite

Ma, Q. and Cheng, L.-p. (2005) Roles of Tlx1 and Tlx3 and Neuronal Activity in Controlling Glutamatergic over GABAergic Cell Fates, in Transcription Factors in the Nervous System: Development, Brain Function, and Diseases (ed G. Thiel), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527608036.ch7

Editor Information

  1. Department of Medical Biochemistry and Molecular Biology, University of Saarland Medical Center, Building 44, 66421 Homburg, Germany

Author Information

  1. 1

    Dana-Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA

  2. 2

    Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China

Publication History

  1. Published Online: 22 MAY 2006
  2. Published Print: 16 DEC 2005

ISBN Information

Print ISBN: 9783527312856

Online ISBN: 9783527608034

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Keywords:

  • transcription factors;
  • neural development;
  • Tlx1 and Tlx3;
  • neuronal activity in controlling glutamatergic over GABAergic cell fates;
  • dorsal horn of spinal cord;
  • Tlx family of homeobox proteins;
  • Tlx gene expression marks sensory circuits;
  • glutamatergic and GABAergic transmitter phenotypes;
  • plasticity of neurotransmitter phenotypes

Summary

This chapter contains sections titled:

  • Abstract

  • Introduction

  • The Dorsal Horn of the Spinal Cord

  • Neurogenesis in the Dorsal Spinal Cord

  • The Tlx Family of Homeobox Proteins

  • Tlx Gene Expression Marks Sensory Circuits

  • Tlx Genes Serve as Binary Switches between Glutamatergic and GABAergic Transmitter Phenotypes

  • Binary Decision between GABAergic and Glutamatergic Cell Fates is a Common Theme

  • Coupling of Generic Transmitter Phenotypes and Region-Specific Neuronal Identities

  • The Plasticity of Neurotransmitter Phenotypes

  • Summary and Unsolved Problems

  • Abbreviations