Chapter 10. Lipid Rafts in Trafficking and Processing of Prion Protein and Amyloid Precursor Protein

  1. Prof. Dr. Christopher J. Fielding3,4
  1. Daniela Sarnataro1,
  2. Vincenza Campana1,2,
  3. Chiara Zurzolo1,2

Published Online: 6 JUN 2006

DOI: 10.1002/3527608079.ch10

Book Title

Lipid Rafts and Caveolae: From Membrane Biophysics to Cell Biology

Lipid Rafts and Caveolae: From Membrane Biophysics to Cell Biology

Additional Information

How to Cite

Sarnataro, D., Campana, V. and Zurzolo, C. (2006) Lipid Rafts in Trafficking and Processing of Prion Protein and Amyloid Precursor Protein, in Lipid Rafts and Caveolae: From Membrane Biophysics to Cell Biology (ed C. J. Fielding), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527608079.ch10

Editor Information

  1. 3

    Cardiovascular Research Institute and Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA

  2. 4

    Cardiovascular Research Institute and Department of Physiology, University of California San Francisco, San Francisco, CA 94143, USA

Author Information

  1. 1

    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Centro di Endocrinologia ed Oncologia, Sperimentale del Consiglio Nazionale, delle Ricerche, Università degli Studi di Napoli, Federico II, 80131 Napoli, Italy

  2. 2

    Unité de Trafic Membranaire et Pathogénèse, Institut Pasteur, 25 rue du Dr. Roux, 75724 Paris Cedex 15, France

Publication History

  1. Published Online: 6 JUN 2006
  2. Published Print: 9 JAN 2006

ISBN Information

Print ISBN: 9783527312610

Online ISBN: 9783527608072

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Keywords:

  • lipid rafts in trafficking and processing of prion protein and amyloid precursor protein;
  • lipid rafts and caveolae;
  • biochemical properties and functions;
  • PrPc and prion diseases;
  • role of lipid rafts in PrPSc formation;
  • Alzheimer's disease

Summary

This chapter contains sections titled:

  • Introduction

  • Lipid Rafts and Caveolae

    • Biochemical Properties and Functions

  • PrPc and Prion Diseases

    • The Site of PrPc Conversion: The Role of Rafts in the Different Intracellular Compartments

    • Role of Lipid Rafts in PrPSc Formation

    • Mechanism of Raft Action in Prion Conversion

    • Role of Rafts in Proteolytic Attack on PrPc

  • Alzheimer's Disease: The Role of Rafts in APP Trafficking and Processing

    • The “History” of APP Cleavage

    • Intracellular Compartments and Aβ Generation: Involvement of Lipid Rafts

    • The Role of Rafts in β-Secretase Activity

    • The Role of Caveolae/Lipid Rafts in α-Secretase Activity

      • The Role of Lipid Rafts in this Event

    • The Role of Caveolae/Rafts in γ-Secretase Activity

    • The Contribution of Cholesterol and Sphingolipids in APP Processing

  • Conclusions

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