Chapter 12. The Role of Caveolin-1 in Tumor Cell Survival and Cancer Progression

  1. Prof. Dr. Christopher J. Fielding2,3
  1. Dana Ravid,
  2. Mordechai Liscovitch

Published Online: 6 JUN 2006

DOI: 10.1002/3527608079.ch12

Book Title

Lipid Rafts and Caveolae: From Membrane Biophysics to Cell Biology

Lipid Rafts and Caveolae: From Membrane Biophysics to Cell Biology

Additional Information

How to Cite

Ravid, D. and Liscovitch, M. (2006) The Role of Caveolin-1 in Tumor Cell Survival and Cancer Progression, in Lipid Rafts and Caveolae: From Membrane Biophysics to Cell Biology (ed C. J. Fielding), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527608079.ch12

Editor Information

  1. 2

    Cardiovascular Research Institute and Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA

  2. 3

    Cardiovascular Research Institute and Department of Physiology, University of California San Francisco, San Francisco, CA 94143, USA

Author Information

  1. Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel

Publication History

  1. Published Online: 6 JUN 2006
  2. Published Print: 9 JAN 2006

ISBN Information

Print ISBN: 9783527312610

Online ISBN: 9783527608072

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CHAPTER TOOLS

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Keywords:

  • role of caveolin-1 in tumor cell survival and cancer progression;
  • caveolin-1 gene and its regulation during differentiation and transformation;
  • divergent expression of caveolin-1 in human cancer;
  • lung cancer;
  • actions of caveolin-1 in cancer cells;
  • molecular mechanisms implicated in the pro-survival action of caveolin-1;
  • role of Tyr14 phosphorylation in caveolin-1-mediated signaling;
  • stress-induced changes in caveolin-1 expression

Summary

This chapter contains sections titled:

  • Introduction

  • The Caveolin-1 Gene and its Regulation During Differentiation and Transformation

  • Divergent Expression of Caveolin-1 in Human Cancer: The Case of Lung Cancer

  • Actions of Caveolin-1 in Cancer Cells: Effects of Heterologous Expression and Genetic or Functional Suppression

    • Anti-Proliferative Activity of Caveolin-1

    • Pro-Apoptotic Activity of Caveolin-1

    • Survival-Promoting Activity of Caveolin-1

  • Molecular Mechanisms Implicated in the Pro-Survival Action of Caveolin-1

  • The Role of Tyr14 Phosphorylation in Caveolin-1-Mediated Signaling

  • Stress-Induced Changes in Caveolin-1 Expression

  • Concluding Remarks

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