Chapter 6. Phosphorylation of Caveolin and Signaling from Caveolae

  1. Prof. Dr. Christopher J. Fielding2,3
  1. Cynthia Corley Mastick,
  2. Amy Sanguinetti,
  3. Haiming Cao,
  4. Suhani Thakker

Published Online: 6 JUN 2006

DOI: 10.1002/3527608079.ch6

Book Title

Lipid Rafts and Caveolae: From Membrane Biophysics to Cell Biology

Lipid Rafts and Caveolae: From Membrane Biophysics to Cell Biology

Additional Information

How to Cite

Mastick, C. C., Sanguinetti, A., Cao, H. and Thakker, S. (2006) Phosphorylation of Caveolin and Signaling from Caveolae, in Lipid Rafts and Caveolae: From Membrane Biophysics to Cell Biology (ed C. J. Fielding), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527608079.ch6

Editor Information

  1. 2

    Cardiovascular Research Institute and Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA

  2. 3

    Cardiovascular Research Institute and Department of Physiology, University of California San Francisco, San Francisco, CA 94143, USA

Author Information

  1. Department of Biochemistry and Molecular Biology, School of Medicine and College of Agriculture, Biotechnology, and Natural Resources, University of Nevada, Reno, NV 89557, USA

Publication History

  1. Published Online: 6 JUN 2006
  2. Published Print: 9 JAN 2006

ISBN Information

Print ISBN: 9783527312610

Online ISBN: 9783527608072

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CHAPTER TOOLS

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Keywords:

  • phosphorylation of caveolin and signaling from caveolae;
  • signaling pathways leading to caveolin tyrosine phosphorylation;
  • Abl a caveolin kinase;
  • signaling pathways downstream of caveolin tyrosine phosphorylation

Summary

This chapter contains sections titled:

  • Introduction

  • Signaling Pathways Leading to Caveolin Tyrosine Phosphorylation

    • Caveolins-1 and -2 are Phosphorylated in Response to Insulin in Adipocytes

    • The Caveolins are not Direct Substrates of the Insulin Receptor

    • Src-Family Kinases and Stress-Induced Caveolin Phosphorylation

    • Non-Receptor Tyrosine Kinases and Insulin-Induced Caveolin Phosphorylation

    • Abl is a Caveolin Kinase

    • Abl and Fyn Cooperate in the Caveolin Phosphorylation Signaling Pathway

    • Model of the Interaction of Fyn and Abl in Caveolin Phosphorylation

  • Signaling Pathways Downstream of Caveolin Tyrosine Phosphorylation

    • Csk Binds to Phosphocaveolin

    • Regulation of Src-Family Kinases by Csk

    • Feedback Inhibition of Fyn Through Activation of Csk

    • Phosphocaveolin in the Loop

    • Src-Family Kinases, Csk and Actin Remodeling

    • Phosphocaveolin is Enriched at Sites of Attachment of the Actin Cytoskeleton to the Plasma Membrane

    • Abl in the Loop

    • Abl and Actin Remodeling

    • Insulin-Induced Actin Remodeling, GluT4 Translocation, and Caveolae

    • The Role of Caveolin Phosphorylation in Cells

  • Summary

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