Chapter 7. Role of Lipid Microdomains in the Formation of Supramolecular Protein Complexes and Transmembrane Signaling

  1. Prof. Dr. Christopher J. Fielding4,5
  1. György Vámosi1,
  2. Andrea Bodnár1,
  3. György Vereb2,
  4. János Szöllösi3,
  5. Sándor Damjanovich3

Published Online: 6 JUN 2006

DOI: 10.1002/3527608079.ch7

Book Title

Lipid Rafts and Caveolae: From Membrane Biophysics to Cell Biology

Lipid Rafts and Caveolae: From Membrane Biophysics to Cell Biology

Additional Information

How to Cite

Vámosi, G., Bodnár, A., Vereb, G., Szöllösi, J. and Damjanovich, S. (2006) Role of Lipid Microdomains in the Formation of Supramolecular Protein Complexes and Transmembrane Signaling, in Lipid Rafts and Caveolae: From Membrane Biophysics to Cell Biology (ed C. J. Fielding), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527608079.ch7

Editor Information

  1. 4

    Cardiovascular Research Institute and Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA

  2. 5

    Cardiovascular Research Institute and Department of Physiology, University of California San Francisco, San Francisco, CA 94143, USA

Author Information

  1. 1

    Cell Biophysics Research Group of the Hungarian Academy of Sciences, Medical and Health Science Center, Research Center for Molecular Medicine, University of Debrecen, Nagyerdei krt. 98, 4012 Debrecen, Hungary

  2. 2

    Department of Biophysics and Cell Biology, Medical and Health Science Center, Research Center for Molecular Medicine, University of Debrecen, Nagyerdei krt. 98, 4012 Debrecen, Hungary

  3. 3

    Cell Biophysics Research Group of the Hungarian Academy of Sciences and Department of Biophysics and Cell Biology, Medical and Health Science Center, Research Center for Molecular Medicine, University of Debrecen, Nagyerdei krt. 98, 4012 Debrecen, Hungary

Publication History

  1. Published Online: 6 JUN 2006
  2. Published Print: 9 JAN 2006

ISBN Information

Print ISBN: 9783527312610

Online ISBN: 9783527608072

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Keywords:

  • role of lipid microdomains in the formation of supramolecular protein complexes;
  • transmembrane signaling;
  • lateral organization of membrane proteins;
  • organization of membrane proteins;
  • fluorescence resonance energy transfer (FRET);
  • atomic force microscopy (AFM);
  • immunological synapse;
  • voltage-gated K+ channels in lipid rafts;
  • lipid rafts as platforms for cytokine receptor assembly and signaling

Summary

This chapter contains sections titled:

  • Introduction

    • Lateral organization of membrane proteins

    • Factors controlling the organization of membrane proteins

  • Biophysical Strategies for Studying the Lateral Organization of Membrane Proteins

    • Determination of Domain Size and Overlap between Fluorescence Distributions using Fluorescence Microscopy

    • Fluorescence Resonance Energy Transfer (FRET)

    • Fluorescence Cross-Correlation Spectroscopy: Analysis of Protein Co-Mobility

    • Atomic Force Microscopy (AFM)

    • Scanning Near-Field Optical Microscopy (SNOM)

  • The Immunological Synapse

  • Voltage-Gated K+ Channels in Lipid Rafts: Possible Involvement in Local Regulatory Processes

  • Cell Fusion as a Tool for Studying Dynamic Behavior of Protein Clusters

  • Lipid Rafts as Platforms for Cytokine Receptor Assembly and Signaling

  • Organization and Function of Receptor Tyrosine Kinases is Linked to Lipid Microdomains

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