Chapter 16. Mechanical Properties of Single Molecules: A Theoretical Approach

  1. Dr. Paolo Samorì3,4
  1. Pasquale De Santis1,
  2. Raffaella Paparcone1,
  3. Maria Savino2 and
  4. Anita Scipioni1

Published Online: 29 JUN 2006

DOI: 10.1002/3527608516.ch16

Scanning Probe Microscopies Beyond Imaging: Manipulation of Molecules and Nanostructures

Scanning Probe Microscopies Beyond Imaging: Manipulation of Molecules and Nanostructures

How to Cite

De Santis, P., Paparcone, R., Savino, M. and Scipioni, A. (2006) Mechanical Properties of Single Molecules: A Theoretical Approach, in Scanning Probe Microscopies Beyond Imaging: Manipulation of Molecules and Nanostructures (ed P. Samorì), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527608516.ch16

Editor Information

  1. 3

    Istituto per la Sintesi Organica e la Fotoreattività, Consiglio Nazionale delle Ricerche, via Gobetti 101, 40129 Bologna, Italy

  2. 4

    Institut de Science et d'Ingénierie, Supramoléculaires (ISIS), Université Louis Pasteur, 8 allée Gaspard Monge, 67083 Strasbourg, France

Author Information

  1. 1

    Dipartimento di Chimica, Università di Roma “La Sapienza”, P. le A. Moro 5, 00185 Roma, Italy

  2. 2

    Dipartimento di Genetica e Biologia Molecolare, Fondazione Pasteur-Cenci Bolognetti, Università di Roma ‘La Sapienza’, P. le A. Moro 5, 00185 Roma, Italy

Publication History

  1. Published Online: 29 JUN 2006
  2. Published Print: 6 JUN 2006

ISBN Information

Print ISBN: 9783527312696

Online ISBN: 9783527608515

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Keywords:

  • mechanical properties of single molecules;
  • DNA curvature;
  • DNA flexibility;
  • worm-like chain model;
  • DNA persistence length in two dimensions;
  • symmetry of palindromic DNA images

Summary

This chapter contains sections titled:

  • Introduction

  • DNA Curvature

  • DNA Flexibility

  • The Worm-Like Chain Model

  • DNA Persistence Length in Two Dimensions

  • A Model for Predicting the DNA Intrinsic Curvature and Flexibility

  • Mapping Sequence-Dependent DNA Curvature and Flexibility from Microscopy Images

  • The Ensemble Curvature and the Corresponding Standard Deviation for a Segmented DNA

  • The Symmetry of Palindromic DNA Images

  • Experimental Evidence of DNA Sequence Recognition by Mica Surfaces

  • Comparison between Theoretical and Experimental DNA Curvature and Flexibility

  • Sequence-Dependent DNA Dynamics from SFM Time-Resolved DNA Images

  • Conclusions