Chapter 1. Overview of Autophagy

  1. Prof. Dr. Vojo Deretic
  1. Julie E. Legakis1 and
  2. Daniel J. Klionsky2

Published Online: 28 AUG 2006

DOI: 10.1002/352760880X.ch1

Autophagy in Immunity and Infection: A Novel Immune Effector

Autophagy in Immunity and Infection: A Novel Immune Effector

How to Cite

Legakis, J. E. and Klionsky, D. J. (2006) Overview of Autophagy, in Autophagy in Immunity and Infection: A Novel Immune Effector (ed V. Deretic), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/352760880X.ch1

Editor Information

  1. Departments of Molecular Genetics & Microbiology and Cell Biology & Physiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131-001, USA

Author Information

  1. 1

    Life Sciences Institute, Department of Molecular, Cellular and Developmental Biology, University of Michigan, 210 Washtenaw Ave, Ann Arbor, MI 48109-2216, USA

  2. 2

    Department of Molecular, Cellular and Developmental Biology, University of Michigan, 210 Washtenaw Ave, Ann Arbor, MI 48109-2216, USA

Publication History

  1. Published Online: 28 AUG 2006
  2. Published Print: 20 JUN 2006

ISBN Information

Print ISBN: 9783527314508

Online ISBN: 9783527608805

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Keywords:

  • autophagy;
  • immunity;
  • infection;
  • discovery of autophagy;
  • mechanistic aspects of autophagy;
  • cargo selection;
  • packaging;
  • vesicle expansion;
  • vesicle completion;
  • targeting

Summary

This chapter contains sections titled:

  • Overview of Autophagy

  • The Discovery of Autophagy

  • Mechanistic Aspects of Autophagy

    • Induction

    • Cargo Selection and Packaging

    • Vesicle Nucleation

    • Vesicle Expansion and Completion

    • Retrieval

    • Targeting, Docking and Fusion of the Vesicle with the Lysosome/Vacuole

    • Breakdown of the Vesicle and its Cargo

  • Autophagy and Immunity

  • References