Chapter 11. Utilization of Endoplasmic Reticulum Membranes to Establish a Vacuole that Supports Replication of Legionella pneumophila

  1. Prof. Dr. Vojo Deretic
  1. Mary-Pat Stein and
  2. Craig R. Roy

Published Online: 28 AUG 2006

DOI: 10.1002/352760880X.ch11

Autophagy in Immunity and Infection: A Novel Immune Effector

Autophagy in Immunity and Infection: A Novel Immune Effector

How to Cite

Stein, M.-P. and Roy, C. R. (2006) Utilization of Endoplasmic Reticulum Membranes to Establish a Vacuole that Supports Replication of Legionella pneumophila, in Autophagy in Immunity and Infection: A Novel Immune Effector (ed V. Deretic), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/352760880X.ch11

Editor Information

  1. Departments of Molecular Genetics & Microbiology and Cell Biology & Physiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131-001, USA

Author Information

  1. Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale University School of Medicine, 295 Congress Ave, New Haven, CT 06536, USA

Publication History

  1. Published Online: 28 AUG 2006
  2. Published Print: 20 JUN 2006

ISBN Information

Print ISBN: 9783527314508

Online ISBN: 9783527608805

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Keywords:

  • autophagy;
  • immunity;
  • infection;
  • Legionella pneumophila;
  • utilization of endoplasmic reticulum membranes;
  • autophagy machinery;
  • biogenesis of replicative organelle;
  • autophagosomes;
  • fusion with lysosomes

Summary

This chapter contains sections titled:

  • Introduction

  • Evidence that Legionella Utilizes the Autophagy Machinery for Biogenesis of a Replicative Organelle

    • Induction of Autophagy

    • Formation of Autophagosomes

    • Maturation of Autophagosomes and Fusion with Lysosomes

  • Evidence that the Host Autophagy Machinery is not Essential for Transport or Growth of Legionella

    • Dictyostelium discoideum Autophagy Mutants Support Legionella Growth

    • Morphological Differences between LCVs and Autophagosomes

    • Differences Between Legionella and Other Bacteria that Utilize Autophagy for Intracellular Survival

  • Creation of an ER-derived Vacuole that Supports Legionella Replication by Subversion of the Host Secretory Pathway

  • Conclusion

  • References