Chapter 12. Endogenous Major Histocompatibility Complex Class II Antigen Processing of Viral Antigens

  1. Prof. Dr. Vojo Deretic
  1. Dorothee Schmid and
  2. Christian Münz

Published Online: 28 AUG 2006

DOI: 10.1002/352760880X.ch12

Autophagy in Immunity and Infection: A Novel Immune Effector

Autophagy in Immunity and Infection: A Novel Immune Effector

How to Cite

Schmid, D. and Münz, C. (2006) Endogenous Major Histocompatibility Complex Class II Antigen Processing of Viral Antigens, in Autophagy in Immunity and Infection: A Novel Immune Effector (ed V. Deretic), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/352760880X.ch12

Editor Information

  1. Departments of Molecular Genetics & Microbiology and Cell Biology & Physiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131-001, USA

Author Information

  1. Laboratory of Viral Immunobiology and Christopher H. Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA

Publication History

  1. Published Online: 28 AUG 2006
  2. Published Print: 20 JUN 2006

ISBN Information

Print ISBN: 9783527314508

Online ISBN: 9783527608805

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Keywords:

  • autophagy;
  • immunity;
  • infection;
  • endogenous MHC class II antigen processing;
  • viral antigens;
  • classical pathways of antigen processing;
  • MHC presentation;
  • autophagic delivery of antigens;
  • lysosomal degradation;
  • MHC class II presentation;
  • vesicular transport pathways of autophagosomes;
  • MHC Class II loading compartments

Summary

This chapter contains sections titled:

  • Introduction

  • Classical Pathways of Antigen Processing for MHC Presentation

  • Endogenous MHC Class II Antigen Processing of Viral Antigens

  • Autophagic Delivery of Antigens for Lysosomal Degradation and MHC Class II Presentation

  • Similarities Between Sources of MHC Class II Ligands and Autophagy Substrates

  • Overlap Between the Vesicular Transport Pathways of Autophagosomes and MHC Class II Loading Compartments

  • Possible Functions of MHC Class II Presentation after Autophagy in the Immune Control of Viral Infections

  • Future Directions of Research into Endogenous MHC Class II Antigen Processing

  • Summary

  • Acknowledgments

  • References