Chapter 3. Transgenic Models of Autophagy

  1. Prof. Dr. Vojo Deretic
  1. Noboru Mizushima

Published Online: 28 AUG 2006

DOI: 10.1002/352760880X.ch3

Autophagy in Immunity and Infection: A Novel Immune Effector

Autophagy in Immunity and Infection: A Novel Immune Effector

How to Cite

Mizushima, N. (2006) Transgenic Models of Autophagy, in Autophagy in Immunity and Infection: A Novel Immune Effector (ed V. Deretic), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/352760880X.ch3

Editor Information

  1. Departments of Molecular Genetics & Microbiology and Cell Biology & Physiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131-001, USA

Author Information

  1. Department of Bioregulation and Metabolism, Tokyo Metropolitan Institute of Medical Science, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8613, Japan

Publication History

  1. Published Online: 28 AUG 2006
  2. Published Print: 20 JUN 2006

ISBN Information

Print ISBN: 9783527314508

Online ISBN: 9783527608805



  • autophagy;
  • immunity;
  • infection;
  • transgenic models of autophagy;
  • molecular mechanism;
  • mammalian autophagy;
  • autophagy indicator mice;
  • mouse models;
  • deficient for autophagy-related genes


This chapter contains sections titled:

  • Molecular Mechanism of Mammalian Autophagy

    • Atg12 Conjugation System

    • Atg8/Microtubule-associated Protein 1 Light Chain 3 (LC3) Conjugation System

    • Class III Phosphatidylinositol-3-kinase (PI3K) Complex

    • Atg1 Kinase Complex

    • Other Factors

  • Autophagy Indicator Mice: Green Fluorescent Protein (GFP)–LC3 Transgenic Mice

  • Mouse Models Deficient for Autophagy-related Genes

    • Atg5-deficient Mice

    • Atg7-deficient Mice

    • Beclin 1-deficient Mice

  • Concluding Remarks

  • References