Chapter 7. Autophagy Eliminates Group A Streptococcus Invading Host Cells

  1. Prof. Dr. Vojo Deretic
  1. Atsuo Amano1 and
  2. Tamotsu Yoshimori2

Published Online: 28 AUG 2006

DOI: 10.1002/352760880X.ch7

Autophagy in Immunity and Infection: A Novel Immune Effector

Autophagy in Immunity and Infection: A Novel Immune Effector

How to Cite

Amano, A. and Yoshimori, T. (2006) Autophagy Eliminates Group A Streptococcus Invading Host Cells, in Autophagy in Immunity and Infection: A Novel Immune Effector (ed V. Deretic), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/352760880X.ch7

Editor Information

  1. Departments of Molecular Genetics & Microbiology and Cell Biology & Physiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131-001, USA

Author Information

  1. 1

    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, 1–8 Yamadaoka, Suita-Osaka 565-0871, Japan

  2. 2

    Department of Cell Genetics, National Institute of Genetics, Sokendai, Yata 1111, Mishima, Shizuoka-ken 411-8540, Japan

Publication History

  1. Published Online: 28 AUG 2006
  2. Published Print: 20 JUN 2006

ISBN Information

Print ISBN: 9783527314508

Online ISBN: 9783527608805

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Keywords:

  • autophagy;
  • immunity;
  • infection;
  • autophagy eliminates group A Streptococcus (GAS);
  • adherence;
  • invasion;
  • survival of intracellular bacteria;
  • streptolysin O (SLO);
  • escape form phagocytic/endocytic degradation;
  • Atg5 capture and killing of GAS

Summary

This chapter contains sections titled:

  • Group A Streptococcus (GAS; Streptococcus pyogenes)

  • Adherence to Host Cells by GAS

  • Invasion of Host Cells by GAS

  • Survival of Intracellular Bacteria

  • Streptolysin O (SLO) Enables GAS to Escape form Phagocytic/Endocytic Degradation

  • Autophagy

  • Intracellular GAS is Trapped by Autophagosome-like Compartments

  • Atg5 is Required for Capture and Killing of GAS

  • GcAVs Fuse with Lysosomes for Degradation

  • Conclusion and Perspective

  • References