Chapter 11. The Healthy Cortisol Response

  1. Prof. Dr. Bengt B. Arnetz3,4 and
  2. Prof. Rolf Ekman5
  1. Tommy Olsson1 and
  2. Robert Sapolsky2

Published Online: 21 AUG 2006

DOI: 10.1002/3527609156.ch11

Stress in Health and Disease

Stress in Health and Disease

How to Cite

Olsson, T. and Sapolsky, R. (2006) The Healthy Cortisol Response, in Stress in Health and Disease (eds B. B. Arnetz and R. Ekman), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527609156.ch11

Editor Information

  1. 3

    Division of Occupational and Environmental Medicine, Wayne State University, 101 E. Alexandrine, Detroit, Michigan 48201-2011, USA

  2. 4

    Division of Social Medicine, Uppsala University, Uppsala Science Park, Social Medicine, 75185 Uppsala, Sweden

  3. 5

    Institute of Neuroscience and Physiology, Neurochemical laboratory, Mölndal/SU, 43180 Mölndal, Sweden

Author Information

  1. 1

    Department of Public Health and Clinical Medicine, Umeå University Hospital, 90185 Umeå, Sweden

  2. 2

    Departments of Biological Sciences, Neurology and Neurological Sciences, Stanford University, MC 5020, Stanford, CA 94305-5020, USA

Publication History

  1. Published Online: 21 AUG 2006
  2. Published Print: 20 JUL 2006

ISBN Information

Print ISBN: 9783527312214

Online ISBN: 9783527609154



  • stress in health and disease;
  • stress and brain plasticity;
  • healthy cortisol response;
  • hippocampus as a GC target;
  • glucocorticoids;
  • clinical implications


This chapter contains sections titled:

  • Introduction

  • The Hippocampus as a GC Target

  • Glucocorticoids, Stress and Synaptic Plasticity in the Hippocampus

  • Glucocorticoids, Stress and Hippocampal-Dependent Cognition

  • Glucocorticoids, Stress and Neurogenesis

  • Glucocorticoids, Stress and Atrophy of Dendritic Processes

  • Glucocorticoids, Stress and Neurotoxicity

  • Glucocorticoids, Stress and the Endangerment of Hippocampal Neurons

    • Disruption of Neuronal Energetics

    • Endangering GC Actions that are Independent of Energetic Effects

    • Disruption of Cellular Defenses

    • Glucocorticoid Endangerment and Apoptosis

    • Glucocorticoid Endangerment and Inflammation

  • Clinical Implications

  • Main Points

  • Future

  • References