Chapter 23. Stress and Addiction

  1. Prof. Dr. Bengt B. Arnetz2,3 and
  2. Prof. Rolf Ekman4
  1. Bo Söderpalm and
  2. Anna Söderpalm

Published Online: 21 AUG 2006

DOI: 10.1002/3527609156.ch23

Stress in Health and Disease

Stress in Health and Disease

How to Cite

Söderpalm, B. and Söderpalm, A. (2006) Stress and Addiction, in Stress in Health and Disease (eds B. B. Arnetz and R. Ekman), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527609156.ch23

Editor Information

  1. 2

    Division of Occupational and Environmental Medicine, Wayne State University, 101 E. Alexandrine, Detroit, Michigan 48201-2011, USA

  2. 3

    Division of Social Medicine, Uppsala University, Uppsala Science Park, Social Medicine, 75185 Uppsala, Sweden

  3. 4

    Institute of Neuroscience and Physiology, Neurochemical laboratory, Mölndal/SU, 43180 Mölndal, Sweden

Author Information

  1. Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, 41345 Göteborg, Sweden

Publication History

  1. Published Online: 21 AUG 2006
  2. Published Print: 20 JUL 2006

ISBN Information

Print ISBN: 9783527312214

Online ISBN: 9783527609154



  • stress in health and disease;
  • stress and the individual;
  • stress and addiction;
  • stress;
  • alcohol;
  • nicotine;
  • stress and inhibitory control;
  • stress-sensitivity;
  • risk for excessive drug self-administration;
  • human studies


This chapter contains sections titled:

  • Introduction

  • Stress, Alcohol and Nicotine

  • What Are the Biological Underpinnings?

    • Animal Experimental Models

    • Stress and Self-Administration of Dependence-Producing Drugs in Experimental Animals

      • Drugs of Abuse and the Hypothalamic–Pituitary–Adrenocortical Axis

    • Neurobiological Correlates to Stress-Induced Drug Intake

      • The Mesocorticolimbic Dopamine System

      • Sensitization

    • Stress, Sensitization and the Mesocorticolimbic Dopamine System

  • Stress and Inhibitory Control

  • Stress-Sensitivity and Risk for Excessive Drug Self-Administration

  • Human Studies

    • Stress and Gender

    • Sensitization in Humans?

  • Summary

  • References