Chapter 1. The Development of Clinical Trials

  1. David Machin1,2,3,
  2. Simon Day4 and
  3. Sylvan Green5
  1. Simon Day

Published Online: 17 MAY 2007

DOI: 10.1002/9780470010167.ch1

Textbook of Clinical Trials, Second Edition

Textbook of Clinical Trials, Second Edition

How to Cite

Day, S. (2006) The Development of Clinical Trials, in Textbook of Clinical Trials, Second Edition (eds D. Machin, S. Day and S. Green), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470010167.ch1

Editor Information

  1. 1

    Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 16910, Singapore

  2. 2

    UK Children's Cancer Study Group, University of Leicester, UK

  3. 3

    Medical Statistics Group, School of Health and Related Sciences, University of Sheffield, UK

  4. 4

    Licensing Division, Medicines and Healthcare products Regulatory Agency, Room 13–205 Market Towers, 1 Nine Elms Lane, London SW8 5NQ, UK

  5. 5

    Arizona Cancer Centre, Tucson, Arizona, USA

Author Information

  1. Licensing Division, Medicines and Healthcare products Regulatory Agency, Room 13–205 Market Towers, 1 Nine Elms Lane, London SW8 5NQ, UK

Publication History

  1. Published Online: 17 MAY 2007
  2. Published Print: 24 NOV 2006

ISBN Information

Print ISBN: 9780470010143

Online ISBN: 9780470010167

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Keywords:

  • early anecdotal reports of medicines;
  • clinical trial development;
  • experimental design randomisation;
  • blinding and ethics;
  • clinical trial impact on pharmaceutical industry

Summary

This chapter contains sections titled:

  • Introduction

  • Earliest Stories

  • Randomisation

  • Blinding

  • Ethics

  • The Pharmaceutical Industry

  • Data Monitoring

  • Recent Years

  • Acknowledgements

  • References