Chapter 13. Acute Stroke

  1. David Machin2,3,4,
  2. Simon Day5 and
  3. Sylvan Green6
  1. Philip Bath

Published Online: 17 MAY 2007

DOI: 10.1002/9780470010167.ch13

Textbook of Clinical Trials, Second Edition

Textbook of Clinical Trials, Second Edition

How to Cite

Bath, P. (2006) Acute Stroke, in Textbook of Clinical Trials, Second Edition (eds D. Machin, S. Day and S. Green), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470010167.ch13

Editor Information

  1. 2

    Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 16910, Singapore

  2. 3

    UK Children's Cancer Study Group, University of Leicester, UK

  3. 4

    Medical Statistics Group, School of Health and Related Sciences, University of Sheffield, UK

  4. 5

    Licensing Division, Medicines and Healthcare products Regulatory Agency, Room 13–205 Market Towers, 1 Nine Elms Lane, London SW8 5NQ, UK

  5. 6

    Arizona Cancer Centre, Tucson, Arizona, USA

Author Information

  1. Division of Stroke Medicine, Institute of Neuroscience, University of Nottingham, D Floor South Block, Queen's Medical Centre, Nottingham NG7 2UH, UK

Publication History

  1. Published Online: 17 MAY 2007
  2. Published Print: 24 NOV 2006

ISBN Information

Print ISBN: 9780470010143

Online ISBN: 9780470010167



  • acute stroke;
  • acute ischaemic stroke;
  • baseline severity/impairment;
  • inclusion and exclusion criteria in trials;
  • Trial Steering Committee (TSC)


This chapter contains sections titled:

  • Introduction

  • Review Methods

  • Acute Ischaemic Stroke

  • Translating Preclinical Data into Clinical Findings

  • Clinical Development

  • Trial Design

  • Baseline Severity/Impairment

  • Outcomes

  • Sample Size Calculation

  • Inclusion/Exclusion Criteria

  • Randomisation

  • Choice of Centres

  • Analysis

  • Trial Committees

  • Summary

  • Conflicts of Interest

  • References