Chapter 17. HIV Infection

  1. David Machin2,3,4,
  2. Simon Day5 and
  3. Sylvan Green6
  1. Michael D. Hughes

Published Online: 17 MAY 2007

DOI: 10.1002/9780470010167.ch17

Textbook of Clinical Trials, Second Edition

Textbook of Clinical Trials, Second Edition

How to Cite

Hughes, M. D. (2006) HIV Infection, in Textbook of Clinical Trials, Second Edition (eds D. Machin, S. Day and S. Green), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470010167.ch17

Editor Information

  1. 2

    Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 16910, Singapore

  2. 3

    UK Children's Cancer Study Group, University of Leicester, UK

  3. 4

    Medical Statistics Group, School of Health and Related Sciences, University of Sheffield, UK

  4. 5

    Licensing Division, Medicines and Healthcare products Regulatory Agency, Room 13–205 Market Towers, 1 Nine Elms Lane, London SW8 5NQ, UK

  5. 6

    Arizona Cancer Centre, Tucson, Arizona, USA

Author Information

  1. Center for Biostatistics in AIDS Research, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA

Publication History

  1. Published Online: 17 MAY 2007
  2. Published Print: 24 NOV 2006

ISBN Information

Print ISBN: 9780470010143

Online ISBN: 9780470010167



  • human immunodeficiency virus (HIV) infection epidemic;
  • HAART regimens for HIV-infected patients;
  • ‘time-to-loss-of-virologic-response’ (TLOVR terminology);
  • ‘optimised background regimen’ (OBR);
  • SMART Study - key treatment management question


This chapter contains sections titled:

  • Introduction

  • HIV and its Treatment

  • Phase I/II Clinical Trials

  • Phase III Clinical Trials

  • Treatment Management Trials

  • Other Issues

  • References