Chapter 22. Psychotherapy for Depression

  1. David Machin2,3,4,
  2. Simon Day5 and
  3. Sylvan Green6
  1. Graham Dunn

Published Online: 17 MAY 2007

DOI: 10.1002/9780470010167.ch22

Textbook of Clinical Trials, Second Edition

Textbook of Clinical Trials, Second Edition

How to Cite

Dunn, G. (2006) Psychotherapy for Depression, in Textbook of Clinical Trials, Second Edition (eds D. Machin, S. Day and S. Green), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470010167.ch22

Editor Information

  1. 2

    Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 16910, Singapore

  2. 3

    UK Children's Cancer Study Group, University of Leicester, UK

  3. 4

    Medical Statistics Group, School of Health and Related Sciences, University of Sheffield, UK

  4. 5

    Licensing Division, Medicines and Healthcare products Regulatory Agency, Room 13–205 Market Towers, 1 Nine Elms Lane, London SW8 5NQ, UK

  5. 6

    Arizona Cancer Centre, Tucson, Arizona, USA

Author Information

  1. Biostatistics Group, Division of Epidemiology and Health Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK

Publication History

  1. Published Online: 17 MAY 2007
  2. Published Print: 24 NOV 2006

ISBN Information

Print ISBN: 9780470010143

Online ISBN: 9780470010167



  • psychotherapy for depression;
  • intention-to-treat (ITT) and average causal effect (ACE);
  • centre, group and therapist effects;
  • causal effect estimation in RCT with non-adherence to allocated treatment;
  • complier average causal effect (CACE) estimation


This chapter contains sections titled:

  • Introduction

  • The Causal Effect of Treatment

  • Comparison of Group Averages and the Role of Randomisation

  • Choice of, and Adherence to, an Appropriate form of Psychotherapy

  • Choice of an Appropriate Control Group

  • Choice of Assessment Method and Outcome Measures

  • Centre, Group and Therapist Effects

  • What Works for Whom?

  • Estimation of Causal Effects in an Rct With Non-Adherence to Allocated Treatment

  • How Much Therapy? ‘Dose’–Response Effects

  • Randomised Consent and Patient Preference Designs

  • Conclusions

  • References