Chapter 25. Early Pregnancy Termination

  1. David Machin3,4,5,
  2. Simon Day6 and
  3. Sylvan Green7
  1. Beverly Winikoff1 and
  2. Batya Elul2

Published Online: 17 MAY 2007

DOI: 10.1002/9780470010167.ch25

Textbook of Clinical Trials, Second Edition

Textbook of Clinical Trials, Second Edition

How to Cite

Winikoff, B. and Elul, B. (2006) Early Pregnancy Termination, in Textbook of Clinical Trials, Second Edition (eds D. Machin, S. Day and S. Green), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470010167.ch25

Editor Information

  1. 3

    Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 16910, Singapore

  2. 4

    UK Children's Cancer Study Group, University of Leicester, UK

  3. 5

    Medical Statistics Group, School of Health and Related Sciences, University of Sheffield, UK

  4. 6

    Licensing Division, Medicines and Healthcare products Regulatory Agency, Room 13–205 Market Towers, 1 Nine Elms Lane, London SW8 5NQ, UK

  5. 7

    Arizona Cancer Centre, Tucson, Arizona, USA

Author Information

  1. 1

    Gynuity Health Projects, New York, NY 10010, USA

  2. 2

    Mailman School of Public Health, Columbia University, New York, NY 10034, USA

Publication History

  1. Published Online: 17 MAY 2007
  2. Published Print: 24 NOV 2006

ISBN Information

Print ISBN: 9780470010143

Online ISBN: 9780470010167



  • early pregnancy terminations;
  • manual vacuum aspiration (MVA), electric vacuum aspiration (EVA), and dilatation and curettage (D&C);
  • surgical and medical abortion;
  • blinding - therapy or intervention concealment;
  • Pain management and surgical abortion


This chapter contains sections titled:

  • Introduction

  • Background: Methods of Early Pregnancy Termination

  • Methodological Issues: Outcome Measures

  • Methodological Issues: Study Design

  • Summary

  • Acknowledgements

  • References