Chapter 28. Anaesthesia and Pain

  1. David Machin3,4,5,
  2. Simon Day6 and
  3. Sylvan Green7
  1. Paul S. Myles1 and
  2. John Rigg2

Published Online: 17 MAY 2007

DOI: 10.1002/9780470010167.ch28

Textbook of Clinical Trials, Second Edition

Textbook of Clinical Trials, Second Edition

How to Cite

Myles, P. S. and Rigg, J. (2006) Anaesthesia and Pain, in Textbook of Clinical Trials, Second Edition (eds D. Machin, S. Day and S. Green), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470010167.ch28

Editor Information

  1. 3

    Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 16910, Singapore

  2. 4

    UK Children's Cancer Study Group, University of Leicester, UK

  3. 5

    Medical Statistics Group, School of Health and Related Sciences, University of Sheffield, UK

  4. 6

    Licensing Division, Medicines and Healthcare products Regulatory Agency, Room 13–205 Market Towers, 1 Nine Elms Lane, London SW8 5NQ, UK

  5. 7

    Arizona Cancer Centre, Tucson, Arizona, USA

Author Information

  1. 1

    Department of Anaesthesia and Pain Management, Alfred Hospital, Commercial Road, Melbourne, Victoria 3004, Australia

  2. 2

    Department of Anaesthesia and Clinical Perioperative Services, Armadale Health Service, PO Box 460, Armadale, Western Australia 6992, Australia

Publication History

  1. Published Online: 17 MAY 2007
  2. Published Print: 24 NOV 2006

ISBN Information

Print ISBN: 9780470010143

Online ISBN: 9780470010167



  • anaesthesia and pain;
  • mechanistic studies and anaesthetic drug potency;
  • pulmonary artery catheterisation;
  • sequential analysis;
  • evidence-based medicine (EBM) in anaesthesia


This chapter contains sections titled:

  • Introduction

  • Clinical Research Methods

  • Trial Design Issues in Anaesthesia

  • Drug Development Studies

  • Clinical Trial Groups

  • Pragmatic Trials in Anaesthesia

  • References