Chapter 34. Palliative Care

  1. David Machin3,4,5,
  2. Simon Day6 and
  3. Sylvan Green7
  1. Robert S. Krouse1 and
  2. David Casarett2

Published Online: 17 MAY 2007

DOI: 10.1002/9780470010167.ch34

Textbook of Clinical Trials, Second Edition

Textbook of Clinical Trials, Second Edition

How to Cite

Krouse, R. S. and Casarett, D. (2006) Palliative Care, in Textbook of Clinical Trials, Second Edition (eds D. Machin, S. Day and S. Green), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470010167.ch34

Editor Information

  1. 3

    Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 16910, Singapore

  2. 4

    UK Children's Cancer Study Group, University of Leicester, UK

  3. 5

    Medical Statistics Group, School of Health and Related Sciences, University of Sheffield, UK

  4. 6

    Licensing Division, Medicines and Healthcare products Regulatory Agency, Room 13–205 Market Towers, 1 Nine Elms Lane, London SW8 5NQ, UK

  5. 7

    Arizona Cancer Centre, Tucson, Arizona, USA

Author Information

  1. 1

    Surgical Care Line, 2–112, Southern Arizona Veterans Affairs Health Care System, 3601 S. 6th Avenue, Tucson, AZ 85723, USA

  2. 2

    University of Pennsylvania, Philadelphia, PA USA

Publication History

  1. Published Online: 17 MAY 2007
  2. Published Print: 24 NOV 2006

ISBN Information

Print ISBN: 9780470010143

Online ISBN: 9780470010167



  • palliative care and quality of life (QOL);
  • QOL for patient facing end of life (EOL);
  • palliative care research and understanding of EOL care;
  • Mini-Mental State Exam (MMSE);
  • Karnofsky score - surrogate for QOL


This chapter contains sections titled:

  • Introduction

  • Overview of Palliative Care Problems

  • Interdisciplinary Nature of Care for Patients Facing the EOL

  • Importance of Research for Patients Facing the EOL

  • Types of Research Problems

  • Historical Perspective of Trials: Are Palliative Trials ‘Palliative’?

  • Ethical Dilemmas and Barriers to Palliative Care Research

  • Palliative Care Problems and Clinical Trial Methods: Adopting Study Design to Setting and Problem

  • Phase I Studies

  • Phase II Studies

  • Phase III Studies

  • Future Directions

  • References