Chapter 36. Cluster Randomized Trials in Health Care Research

  1. David Machin2,3,4,
  2. Simon Day5 and
  3. Sylvan Green6
  1. Randall D. Cebul,
  2. Neal V. Dawson and
  3. Thomas E. Love

Published Online: 17 MAY 2007

DOI: 10.1002/9780470010167.ch36

Textbook of Clinical Trials, Second Edition

Textbook of Clinical Trials, Second Edition

How to Cite

Cebul, R. D., Dawson, N. V. and Love, T. E. (2006) Cluster Randomized Trials in Health Care Research, in Textbook of Clinical Trials, Second Edition (eds D. Machin, S. Day and S. Green), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470010167.ch36

Editor Information

  1. 2

    Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 16910, Singapore

  2. 3

    UK Children's Cancer Study Group, University of Leicester, UK

  3. 4

    Medical Statistics Group, School of Health and Related Sciences, University of Sheffield, UK

  4. 5

    Licensing Division, Medicines and Healthcare products Regulatory Agency, Room 13–205 Market Towers, 1 Nine Elms Lane, London SW8 5NQ, UK

  5. 6

    Arizona Cancer Centre, Tucson, Arizona, USA

Author Information

  1. Center for Health Care Research and Policy, Case Western Reserve University School of Medicine at MetroHealth Medical Center, Cleveland, Ohio, USA

Publication History

  1. Published Online: 17 MAY 2007
  2. Published Print: 24 NOV 2006

ISBN Information

Print ISBN: 9780470010143

Online ISBN: 9780470010167



  • mantra of health care research - ‘access, cost, and quality’;
  • cluster randomized trials (CRTs) in health care research;
  • effects of clustering;
  • methodologic issues in CRT design, conduct and analysis;
  • CRTs - health care researchers' methodologic armamentarium


This chapter contains sections titled:

  • Introduction and Overview

  • History and Trends in Health Care CRTs

  • Clustering and its Impact

  • Selected Considerations in Planning and Conducting Health Care CRTs

  • Summary

  • Acknowledgements

  • References