Chapter 4. Breast Cancer

  1. David Machin4,5,6,
  2. Simon Day7 and
  3. Sylvan Green8
  1. Donald A. Berry1,
  2. Terry L. Smith2 and
  3. Aman U. Buzdar3

Published Online: 17 MAY 2007

DOI: 10.1002/9780470010167.ch4

Textbook of Clinical Trials, Second Edition

Textbook of Clinical Trials, Second Edition

How to Cite

Berry, D. A., Smith, T. L. and Buzdar, A. U. (2006) Breast Cancer, in Textbook of Clinical Trials, Second Edition (eds D. Machin, S. Day and S. Green), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470010167.ch4

Editor Information

  1. 4

    Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 16910, Singapore

  2. 5

    UK Children's Cancer Study Group, University of Leicester, UK

  3. 6

    Medical Statistics Group, School of Health and Related Sciences, University of Sheffield, UK

  4. 7

    Licensing Division, Medicines and Healthcare products Regulatory Agency, Room 13–205 Market Towers, 1 Nine Elms Lane, London SW8 5NQ, UK

  5. 8

    Arizona Cancer Centre, Tucson, Arizona, USA

Author Information

  1. 1

    Department of Biostatistics, University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd, Box 0447, Houston, TX 77030, USA

  2. 2

    University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd, Box 0447, Houston, TX 77030, USA

  3. 3

    Department of Breast Medical Oncology, University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd, Box 1354, Houston, TX 77030, USA

Publication History

  1. Published Online: 17 MAY 2007
  2. Published Print: 24 NOV 2006

ISBN Information

Print ISBN: 9780470010143

Online ISBN: 9780470010167

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Keywords:

  • breast cancer and staging;
  • breast tumour and oestrogen receptor (ER) status;
  • mammography and hormonal therapy;
  • adaptive designs of clinical trials;
  • time-dependent hazards and Kaplan-Meier survival curves

Summary

This chapter contains sections titled:

  • Introduction

  • Staging

  • Prognosis

  • Historical Perspective on Clinical Trials in Breast Cancer

  • Time-Dependent Hazards

  • Assessing Long-Term Impacts of Therapy

  • Adaptive Designs of Clinical Trials

  • Conclusion

  • References