Chapter 5. Childhood Cancer

  1. David Machin3,4,5,
  2. Simon Day6 and
  3. Sylvan Green7
  1. Sharon B Murphy1 and
  2. Jonathan J. Shuster2

Published Online: 17 MAY 2007

DOI: 10.1002/9780470010167.ch5

Textbook of Clinical Trials, Second Edition

Textbook of Clinical Trials, Second Edition

How to Cite

Murphy, S. B. and Shuster, J. J. (2006) Childhood Cancer, in Textbook of Clinical Trials, Second Edition (eds D. Machin, S. Day and S. Green), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470010167.ch5

Editor Information

  1. 3

    Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 16910, Singapore

  2. 4

    UK Children's Cancer Study Group, University of Leicester, UK

  3. 5

    Medical Statistics Group, School of Health and Related Sciences, University of Sheffield, UK

  4. 6

    Licensing Division, Medicines and Healthcare products Regulatory Agency, Room 13–205 Market Towers, 1 Nine Elms Lane, London SW8 5NQ, UK

  5. 7

    Arizona Cancer Centre, Tucson, Arizona, USA

Author Information

  1. 1

    Children's Cancer Research Institute, Mail Code 7784, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229–3900, USA,

  2. 2

    College of Medicine, University of Florida, PO Box 100212, Gainesville, FL 32610-0212, USA

Publication History

  1. Published Online: 17 MAY 2007
  2. Published Print: 24 NOV 2006

ISBN Information

Print ISBN: 9780470010143

Online ISBN: 9780470010167



  • childhood cancer;
  • lymphomas, Hodgkin disease (HD) and non-Hodgkin lymphomas (NHLs);
  • minimal residual disease (MRD) occurrence;
  • childhood cancer trial study design;
  • future of childhood cancer research


This chapter contains sections titled:

  • Introduction

  • History and Perspectives on Important Paediatric Cancer Clinical Trials

  • Prognostic Factors, Translational Research and Therapeutically Relevant Risk Groups

  • Study Design for Childhood Cancer Trials

  • Ethical and Other Special Considerations Affecting Conduct of Trials in Children with Cancer

  • A Look into the Future of Childhood Cancer Research

  • Acknowledgements

  • References