Chapter 7. Melanoma

  1. David Machin3,4,5,
  2. Simon Day6 and
  3. Sylvan Green7
  1. Ping-Yu Liu1 and
  2. Vernon K. Sondak2

Published Online: 17 MAY 2007

DOI: 10.1002/9780470010167.ch7

Textbook of Clinical Trials, Second Edition

Textbook of Clinical Trials, Second Edition

How to Cite

Liu, P.-Y. and Sondak, V. K. (2007) Melanoma, in Textbook of Clinical Trials, Second Edition (eds D. Machin, S. Day and S. Green), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470010167.ch7

Editor Information

  1. 3

    Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 16910, Singapore

  2. 4

    UK Children's Cancer Study Group, University of Leicester, UK

  3. 5

    Medical Statistics Group, School of Health and Related Sciences, University of Sheffield, UK

  4. 6

    Licensing Division, Medicines and Healthcare products Regulatory Agency, Room 13–205 Market Towers, 1 Nine Elms Lane, London SW8 5NQ, UK

  5. 7

    Arizona Cancer Centre, Tucson, Arizona, USA

Author Information

  1. 1

    Fred Hutchinson Cancer Research Centre, Seattle, WA 98109-1024, USA

  2. 2

    H. Lee Moffitt Cancer Center, The University of South Florida, 12902 Magnolia Dr., Tampa, FL 33612, USA

Publication History

  1. Published Online: 17 MAY 2007
  2. Published Print: 24 NOV 2006

ISBN Information

Print ISBN: 9780470010143

Online ISBN: 9780470010167



  • malignant melanoma;
  • sentinel lymph node biopsy;
  • adjuvant interferon clinical trials;
  • adjuvant vaccine clinical trials;
  • randomised Phase III clinical trials


This chapter contains sections titled:

  • Introduction

  • Background

  • Adjuvant Interferon Clinical Trials

  • Clinical Considerations

  • Statistical Considerations

  • Adjuvant Vaccine Clinical Trials

  • Conclusions

  • References