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Protein Synthesis Initiation in Bacteria

  1. Marianne Grunberg-Manago1,
  2. Sean M Studer2,
  3. Simpson Joseph2

Published Online: 21 DEC 2007

DOI: 10.1002/9780470015902.a0000542.pub2



How to Cite

Grunberg-Manago, M., Studer, S. M. and Joseph, S. 2007. Protein Synthesis Initiation in Bacteria. eLS. .

Author Information

  1. 1

    Institute of Physico-chemical Biology, Paris, France

  2. 2

    University of California, San Diego, CA, USA

Publication History

  1. Published Online: 21 DEC 2007

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Translation initiation begins with the assembly of the pre-initiation complex followed by the formation of the initiation complex. The process of initiation then continues until the first peptide bond is formed; it is at this point that translation begins. The formation of the pre-initiation/initiation complex is often the rate-limiting step during the process of translation, as it is influenced by a number of translational regulatory mechanisms. As a result, the process of initiation can play a significant role in gene expression.


  • initiation factors;
  • translation;
  • Shine–Dalgarno sequence