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Lysosomal Degradation of Proteins

  1. J Fred Dice

Published Online: 16 JUL 2007

DOI: 10.1002/9780470015902.a0000646.pub2

eLS

eLS

How to Cite

Dice, J. F. 2007. Lysosomal Degradation of Proteins. eLS. .

Author Information

  1. Tufts University School of Medicine, Boston, Massachusetts, USA

Publication History

  1. Published Online: 16 JUL 2007

Abstract

Lysosomal enzymes and lysosomal membrane proteins are targeted to lysosomes by distinct mechanisms. Mutations that cause a reduction in activity of a lysosomal enzyme cause a variety of lysosomal storage diseases. Lysosomes are able to take up and degrade proteins by at least five different pathways, and their contribution to overall proteolysis depends on the cell type and its physiological status. Recent studies have begun to define the molecular mechanisms of macroautophagy, microautophagy, and chaperone-mediated autophagy.

Keywords:

  • lysosome biogenesis;
  • lysosomal enzymes;
  • macroautophagy;
  • microautophagy;
  • chaperone-mediated autophagy