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Enzymatic Rate Enhancements

  1. Daniel M Quinn1,
  2. R Steven Sikorski2

Published Online: 21 DEC 2007

DOI: 10.1002/9780470015902.a0000717.pub2

eLS

eLS

How to Cite

Quinn, D. M. and Sikorski, R. S. 2007. Enzymatic Rate Enhancements. eLS. .

Author Information

  1. 1

    The University of Iowa, Iowa City, Iowa, USA

  2. 2

    FutureCeuticals, Momense, Illinois, USA

Publication History

  1. Published Online: 21 DEC 2007

This is not the most recent version of the article. View current version (15 JUL 2014)

Abstract

Enzymatic rate enhancements arise from the unmatched ability of enzymes to stabilize the transition states of the reactions that they catalyse. The purpose of this article is to discuss the magnitude and mechanistic origins of enzymatic rate enhancements. Selected enzymes are described that manifest a wide range of rate enhancements and corresponding catalytic strategies.

Keywords:

  • catalytic acceleration;
  • transition state stabilization;
  • diffusion control;
  • enzyme mechanisms;
  • enzyme catalysis