Neural Development: bHLH Genes
Published Online: 15 FEB 2010
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Philpott, A. 2010. Neural Development: bHLH Genes. eLS. .
- Published Online: 15 FEB 2010
|Classes of genes that regulate neurogenesis||Examples in Drosophila||Examples in vertebrates||Function|
|Proneural genes||Achaete, scute, atonal, asense, daughterless||achaete–scute homologues (ASHs), atonal homologues (ATHs, NeuroDs, Ngns)||bHLH transcription factors that function as positive regulators of neuronal determination and differentiation|
|Prepattern genes||Iroquois complex (caupolican, araucan) and pannier||Irx 1–6(mouse), Xiro1–5(Xenopus)||Transcription factors that regulate the early pattern of bHLH gene expression|
|Neurogenic genes||Notch, Delta and signal-ling pathway components||Notch, Delta and signalling pathway components||Transmembrane receptor signalling pathway that refines the pattern of bHLH expression and regulates commitment to the neural fate|
|Negative regulatory factors||emc, hairy, E(Spl)||Id1–4, HES1,3,5||HLH factors that limit the domains of bHLH expression and function|
|Factors that cooperate with bHLH factors||XMyT1||Zinc-finger transcription factor that confers resistance to lateral inhibition|
|Putative transcriptional targets for bHLH factors||Pox-neuro||Phox2a||Transcription factors that execute the neuronal differentiation programme|