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Neural Development: bHLH Genes

  1. Anna Philpott

Published Online: 15 FEB 2010

DOI: 10.1002/9780470015902.a0000827.pub2

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How to Cite

Philpott, A. 2010. Neural Development: bHLH Genes. eLS. .

Author Information

  1. University of Cambridge, Department of Oncology, Hutchison/MRC Research Centre, Addenbrookes Hospital, Cambridge, UK

Publication History

  1. Published Online: 15 FEB 2010
Table 1. List of genes that are involved in the patterning, function and hierarchy of the neural bHLH genes
Classes of genes that regulate neurogenesisExamples in DrosophilaExamples in vertebratesFunction
Proneural genesAchaete, scute, atonal, asense, daughterlessachaete–scute homologues (ASHs), atonal homologues (ATHs, NeuroDs, Ngns)bHLH transcription factors that function as positive regulators of neuronal determination and differentiation
Prepattern genesIroquois complex (caupolican, araucan) and pannierIrx 1–6(mouse), Xiro1–5(Xenopus)Transcription factors that regulate the early pattern of bHLH gene expression
Neurogenic genesNotch, Delta and signal-ling pathway componentsNotch, Delta and signalling pathway componentsTransmembrane receptor signalling pathway that refines the pattern of bHLH expression and regulates commitment to the neural fate
Negative regulatory factorsemc, hairy, E(Spl)Id1–4, HES1,3,5HLH factors that limit the domains of bHLH expression and function
Factors that cooperate with bHLH factors XMyT1Zinc-finger transcription factor that confers resistance to lateral inhibition
Putative transcriptional targets for bHLH factorsPox-neuroPhox2aTranscription factors that execute the neuronal differentiation programme