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Regulation by Covalent Modification

  1. Bruce L Martin

Published Online: 28 SEP 2007

DOI: 10.1002/9780470015902.a0000866.pub2



How to Cite

Martin, B. L. 2007. Regulation by Covalent Modification. eLS. .

Author Information

  1. University of Minnesota, Twin Cities, Minneapolis, MN, USA

Publication History

  1. Published Online: 28 SEP 2007

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Covalent modifications are enzyme catalysed alterations of synthesized proteins and include the addition or removal of chemical groups. Modifications can target a single type of amino acid or multiple amino acids and will change the chemical properties of the site. Consequences on the structure and functions of the protein modified are manifested providing a sensitive method for cellular regulation.


  • enzyme and metabolic regulation;
  • autoregulation;
  • cascade;
  • cotranslation modification;
  • post-translational modification