Standard Article

Spliceosomal Machinery

  1. Richard J Grainger,
  2. Jean D Beggs

Published Online: 21 DEC 2007

DOI: 10.1002/9780470015902.a0000889.pub2



How to Cite

Grainger, R. J. and Beggs, J. D. 2007. Spliceosomal Machinery. eLS. .

Author Information

  1. University of Edinburgh, Edinburgh, UK

Publication History

  1. Published Online: 21 DEC 2007


‘Spliceosomal Machinery’ describes how various small nuclear ribonucleic acids (snRNAs) and over 100 proteins interact to perform the precise removal of introns from eukaryotic pre-messenger RNAs. The conserved major U2-spliceosome machinery is the main focus of this article and other minor spliceosomes are also described, as well as an introduction to factors involved in regulating splicing.


  • spliceosome;
  • snRNA;
  • snRNP;
  • RNA splicing;
  • intron