Caps on Eukaryotic mRNAs
Published Online: 16 JUL 2007
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Furuichi, Y. and Shatkin, A. J. 2007. Caps on Eukaryotic mRNAs. eLS. .
- Published Online: 16 JUL 2007
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A 5′-terminal cap is added to most eukaryotic cellular and viral pre-messenger ribonucleic acids at an early stage of transcription. Capping is essential and modulates several subsequent events in gene expression including RNA splicing, translation and stability. These and other effects involve cap-binding proteins that recognize the m7GpppN cap structure. Capping proceeds by a similar series of enzymatic steps in a wide range of systems, but differences exist between metazoans and unicellular eukaryotes and viruses, pointing to capping enzymes as potential targets for the development of novel and selective drugs against some fungal, viral and parasitic infections.
- RNA capping;
- RNA methylation;
- cap-binding proteins;
- MRNA stability