Published Online: 15 JUL 2008
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Kalitsis, P. 2008. Centromeres. eLS.
- Published Online: 15 JUL 2008
The centromere is a eukaryotic chromosomal substructure that ensures the accurate segregation of newly replicated chromosomes to daughter cells. It carries out this essential cell cycle process via multiple functions such as, spindle microtubule attachment, mitotic checkpoint control, sister-chromatid cohesion and release and cytokinesis. This article explores the structure and function of the centromere in many well-studied eukaryotic organisms.
- artificial centromere;
- artificial chromosome;
- epigenetic regulation;