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Protein–DNA Interactions: Polyelectrolyte Effects

  1. Ruth M Saecker

Published Online: 28 SEP 2007

DOI: 10.1002/9780470015902.a0001350.pub2



How to Cite

Saecker, R. M. 2007. Protein–DNA Interactions: Polyelectrolyte Effects. eLS. .

Author Information

  1. UW-Madison, Madison, Wisconsin, USA

Publication History

  1. Published Online: 28 SEP 2007


The stability of noncovalent protein–DNA complexes is typically sensitive to the ionic composition of the solution, in a manner that is dependent on the specific ion concentrations and is not a simple ionic strength effect. One important origin of this sensitivity to solution conditions is the polyelectrolyte effect.


  • Protein–nucleic acid interactions;
  • thermodynamics;
  • polyelectrolytes;
  • binding