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Protein–DNA Complexes: Nonspecific

  1. Ruth M Saecker

Published Online: 28 SEP 2007

DOI: 10.1002/9780470015902.a0001358.pub2



How to Cite

Saecker, R. M. 2007. Protein–DNA Complexes: Nonspecific. eLS. .

Author Information

  1. Department of Chemistry UW-Madison, Madison, Wisconsin, USA

Publication History

  1. Published Online: 28 SEP 2007


Nonspecific protein–DNA complexes form largely independently of deoxyribonucleic acid (DNA) sequence or structure. Typically, the thermodynamic driving force for forming these complexes is electrostatic due to the polyelectrolyte (polyanionic) nature of the DNA.


  • nonspecific binding;
  • cooperativity;
  • protein–nucleic interactions;
  • polyelectrolyte effect