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Ion Motive ATPases: P-type ATPases

  1. Jai Moo Shin,
  2. George Sachs

Published Online: 15 SEP 2009

DOI: 10.1002/9780470015902.a0001379.pub2



How to Cite

Shin, J. M. and Sachs, G. 2009. Ion Motive ATPases: P-type ATPases. eLS. .

Author Information

  1. UCLA, Los Angeles, California, USA

Publication History

  1. Published Online: 15 SEP 2009


Regulation of ions such as calcium, sodium and potassium ions is very important for cell life. One of ion-regulating enzymes is classified as ion motive adenosine triphosphatase (ATPase). Ion motive ATPases exchange two different ions across the membrane at the expense of ATP energy. The Ca2+-ATPase transports Ca ion in exchange for H ion; the Na+/K+ or H+/K+ ATPase transports Na ion or hydronium ion from the cytoplasmic region to the exocytoplasmic region with the exchange of K ion from the exoplasmic domain to the cytoplasmic domain. The Ca2+-ATPase has single catalytic subunit. The Na+/K+ and H+/K+ ATPases consist of two subunits α and β. The α subunit is the catalytic subunit, having 10 transmembrane domains. The β subunit is a glycosylated protein.

Key concepts

  • Ion motive ATPases

  • P-type ATPase transport ions across the membrane

  • Regulating ion concentrations.


  • pumps;
  • ATPase;
  • P-type