Published Online: 15 SEP 2009
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Thiagarajan, P. and Narayanan, A. S. 2009. Thrombin. eLS.
- Published Online: 15 SEP 2009
Thrombin is a serine protease that converts fibrinogen to fibrin in blood coagulation. The precursor of thrombin, prothrombin (inactive zymogen), is one of the several coagulation proteins containing γ-carboxyglutamic acid. Prothrombin is synthesized in the liver and secreted into blood circulation, and it is activated by vascular injury by limited proteolysis following upstream activation of the coagulation cascade. Thrombin activity is regulated by serum inhibitors and by its own action. With its procoagulant and anticoagulant functions it plays a central role in thrombosis and haemostasis, and it is an agonist for a number of cellular responses during inflammation and wound repair. Many diseases including stroke and myocardial infarction involve thrombosis; therefore, thrombin is a preferred target of antithrombotic drugs. Drugs available to block thrombin action include heparins, hirudins (lepirudin and bivaliruidin), vitamin K antagonists and a new generation of direct thrombin inhibitors such as dabigatran and argatroban.
Thrombin is a serine protease that converts fibrinogen to fibrin and plays a crucial role in hemostasis and thrombosis.
- vitamin K;
- endothelial cells