Based in part on the previous version of this eLS article ‘Bacterial Antibiotic Resistance’ (2002) by Shahriar Mobashery and Eduardo F Azucena Jr.
Bacterial Antibiotic Resistance
Published Online: 17 FEB 2014
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Martins, A., Spengler, G., Molnár, J. and Amaral, L. 2014. Bacterial Antibiotic Resistance. eLS. .
- Published Online: 17 FEB 2014
The mechanisms by which antibiotic resistance of bacteria takes place are discussed in detail. Among the mechanisms that have been recently elucidated are overexpressed efflux pumps that render the bacterium multidrug resistant; downregulation of porins; target modification; quorum sensing; biofilm production and secretion and plasmids that carry antibiotic resistance genes. The mechanisms discussed also include modulation by agents or genetic regulation that may provide improved antibiotic therapies.
Efflux pumps, porins and plasmid acquisition play an essential role in the development of multidrug resistance by bacteria.
Quorum sensing is essential in biofilm formation.
Efflux pumps must be essential for bacterial communication (quorum sensing).
Quorum sensing must play an important role in the development of resistance and bacterial survival.
Inhibition of EP and QS appear to be crucial to inhibit biofilm formation.
- bacterial resistance;
- efflux pumps;
- quorum sensing;
- target modification;