Standard Article

Non-Hodgkin Lymphomas

  1. Ian T Magrath

Published Online: 21 DEC 2007

DOI: 10.1002/9780470015902.a0002171.pub2

eLS

eLS

How to Cite

Magrath, I. T. 2007. Non-Hodgkin Lymphomas. eLS. .

Author Information

  1. International Network for Cancer Treatment and Research, Brussels, Belgium

Publication History

  1. Published Online: 21 DEC 2007

This is not the most recent version of the article. View current version (16 JUN 2014)

Abstract

Non-Hodgkin lymphomas (NHLs) are malignant neoplasms of lymphocytes – the predominant cells of the immune system – and their precursor cells. Lymphoid cell surface markers, clonal antigen receptor gene rearrangements and genetic lesions necessary for the induction of NHL (in particular, characteristic chromosomal translocations), can be considered as the defining characteristics of malignant lymphoid neoplasms, with the exception of the tumours of natural killer cells, which lack antigen receptor gene rearrangements. Appropriate treatment can control or cure most NHLs, treatment outcome depending upon the category and subtype of NHL and the extent of disease.

Keywords:

  • lymphoma;
  • neoplasia;
  • T cells;
  • B cells;
  • NK cells;
  • chromosomal translocation;
  • chemotherapy