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Chronic Lymphocytic Leukaemia

  1. Claire Dearden

Published Online: 28 SEP 2007

DOI: 10.1002/9780470015902.a0002173.pub2

eLS

eLS

How to Cite

Dearden, C. 2007. Chronic Lymphocytic Leukaemia. eLS. .

Author Information

  1. Royal Marsden NHS Foundation Trust, Sutton, UK

Publication History

  1. Published Online: 28 SEP 2007

This is not the most recent version of the article. View current version (15 JAN 2013)

Abstract

Chronic lymphocytic leukaemia (CLL) results from the expansion of a clone of CD5+ B lymphocytes with distinct morphology and membrane antigens. The clinical course is variable and is determined by the stage of the disease. Genetic abnormalities detected by fluorescence in situ hybridization (FISH) analysis are important determinants of prognosis. Treatment is only indicated in symptomatic patients with active disease.

Keywords:

  • B lymphocytes;
  • lymphocytic leukaemia;
  • lymphocytosis;
  • lymphoma;
  • prolymphocytes;
  • splenectomy;
  • clinical stage;
  • doubling time;
  • FISH