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Cerebrospinal Fluid and its Abnormalities

  1. Michael Chan,
  2. Sepideh Amin-Hanjani

Published Online: 15 JAN 2010

DOI: 10.1002/9780470015902.a0002191.pub2



How to Cite

Chan, M. and Amin-Hanjani, S. 2010. Cerebrospinal Fluid and its Abnormalities. eLS. .

Author Information

  1. University of Illinois at Chicago, Chicago, USA

Publication History

  1. Published Online: 15 JAN 2010
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Figure 1. Pathways of cerebrospinal fluid (CSF) circulation: CSF is formed in the ventricles, circulates to the subarachnoid space and is absorbed into the venous system by the arachnoid villi. Only approximately 25 mL of the 130 mL around the brain and spinal cord is contained within the ventricles; the rest is housed within the subarachnoid space.

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Figure 2. Transport across the choroid epithelium: cerebrospinal fluid (CSF) formation involves both capillary filtration and active epithelial secretion within the choroid plexus. Both active and passive transport processes are demonstrated within the epithelial cells of the plexus, resulting in regulation of CSF composition. With permission from Spector and Johansen 1989.

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Figure 3. T1 weighted axial and sagittal magnetic resonance images of the brain in patients with ((b) and (d)) and without ((a) and (c)) hydrocephalus. The ventricles are markedly enlarged compared to normal. The cerebral aqueduct (arrow) is patent and there is no evidence of obstruction within the ventricular system. This is a case of communicating hydrocephalus.

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Figure 4. Ventriculoperitoneal shunt.