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Epitope Mapping: B-cell Epitopes

  1. GE Morris1,2

Published Online: 28 SEP 2007

DOI: 10.1002/9780470015902.a0002624.pub2

eLS

eLS

How to Cite

Morris, G. 2007. Epitope Mapping: B-cell Epitopes. eLS. .

Author Information

  1. 1

    Wolfson Centre for Inherited Neuromuscular Disease RJAH Orthopaedic Hospital, Oswestry, UK

  2. 2

    Keele University, Keele, Staffordshire, UK

Publication History

  1. Published Online: 28 SEP 2007

Abstract

Immunoglobulin molecules are folded to present a surface structure complementary to a surface feature on the antigen – the epitope is this feature of the antigen. Epitope mapping is the process of locating the antibody-binding site on the antigen, although the term is also applied more broadly to receptor–ligand interactions unrelated to the immune system.

Keywords:

  • antigen;
  • antibody;
  • phage display;
  • mass spectrometry;
  • site-directed mutagenesis;
  • immunoassay