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Posttranslational Processing: Peptide Hormones and Neuropeptide Transmitters

  1. Andrea Varro

Published Online: 21 DEC 2007

DOI: 10.1002/9780470015902.a0002697.pub2

eLS

eLS

How to Cite

Varro, A. 2007. Posttranslational Processing: Peptide Hormones and Neuropeptide Transmitters. eLS. .

Author Information

  1. University of Liverpool, Liverpool, UK

Publication History

  1. Published Online: 21 DEC 2007

Abstract

The regulatory peptides that act as hormones, paracrine messengers or neurotransmitters are generally synthesized initially as large, inactive precursors that are converted to their active forms by a variety of different posttranslational processing steps including cleavage of the peptide chain and modification to individual residues for example by sulfation, phosphorylation, glycosylation and COOH-terminal amidation.

Keywords:

  • regulatory peptides;
  • prohormone convertases;
  • amidation;
  • sulfation;
  • secretory pathway