Posttranslational Processing: Peptide Hormones and Neuropeptide Transmitters

Abstract

The regulatory peptides that act as hormones, paracrine messengers or neurotransmitters are generally synthesized initially as large, inactive precursors that are converted to their active forms by a variety of different posttranslational processing steps including cleavage of the peptide chain and modification to individual residues for example by sulfation, phosphorylation, glycosylation and COOH-terminal amidation.