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History of Oral Contraceptives

  1. Carl Djerassi

Published Online: 15 SEP 2010

DOI: 10.1002/9780470015902.a0003628.pub2



How to Cite

Djerassi, C. 2010. History of Oral Contraceptives. eLS. .

Author Information

  1. Stanford University, Palo Alto, California, USA

Publication History

  1. Published Online: 15 SEP 2010


Progesterone is the naturally occurring female sex hormone acting as nature's contraceptive by preventing women from conceiving during pregnancy. Since it is not orally active, progesterone cannot practically be used as an oral contraceptive. It required the efforts of organic chemists to synthesise steroids that mimic the biological activity of the natural hormone and that are effective by oral administration. The article concludes with the prognosis that the future prospects for developing fundamentally new contraceptives are dim, primarily because the priorities of the international pharmaceutical industry have shifted to diseases of the increasingly geriatric segments of the population of affluent countries.

Key Concepts:

  • The natural female sex hormone progesterone – nature's contraceptive – is not orally active.

  • New synthetic steroids had to be developed, which retained the biological activity of progesterone, but would be orally active.

  • The lead compound, norethindrone, was synthesised in 1951 and all but one of the subsequent steroid oral contraceptives are based on that chemical template.

  • Research in new approaches to contraception has declined dramatically as the pharmaceutical industry has shifted its attention to diseases of the geriatric segment of the population.

  • The prediction is made that the ultimate direction of birth control in the affluent, geriatric countries will consist of cryopreservation of ‘young’ gametes (particularly relevant for females), followed by sterilisation, and recourse to IVF for reproduction, thus completing the divorce of sex from reproduction.


  • norethindrone;
  • progesterone;
  • 19-norprogesterone;
  • the pill;
  • norgestrel;
  • norethynodrel;
  • birth control;
  • gamete preservation;
  • oral contraception;
  • ethynyloestradiol