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T Lymphocytes: Regulatory

  1. Zoltan Fehervari,
  2. Shimon Sakaguchi

Published Online: 15 DEC 2008

DOI: 10.1002/9780470015902.a0004029.pub2



How to Cite

Fehervari, Z. and Sakaguchi, S. 2008. T Lymphocytes: Regulatory. eLS. .

Author Information

  1. Kyoto University, Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto, Japan

Publication History

  1. Published Online: 15 DEC 2008

This is not the most recent version of the article. View current version (15 APR 2016)


CD4+ regulatory (Treg) T cells play a central role in the immune system by potently controlling the responses of other immunocytes. Their activity appears to be essential not only for the maintenance of immunological self-tolerance but potentially also for the control of all physiological immune responses whether against normal self-proteins, microbes or cancerous cells. A fuller understanding of these cells should allow us to effectively exploit their suppressive functions for clinical benefit.


  • CD25+CD4+T cell;
  • Foxp3;
  • IPEX;
  • regulatory T cell;
  • self-tolerance