Standard Article

5′-UTRs and Regulation

  1. Flavio Mignone1,
  2. Graziano Pesole2

Published Online: 28 SEP 2007

DOI: 10.1002/9780470015902.a0005010.pub2



How to Cite

Mignone, F. and Pesole, G. 2007. 5′-UTRs and Regulation. eLS. .

Author Information

  1. 1

    University of Milan, Milan, Italy

  2. 2

    University of Bari, Bari, Italy

Publication History

  1. Published Online: 28 SEP 2007


The 5′ untranslated region consists of the leading part of a cellular messenger ribonucleic acid (mRNA) from the 5′ end to the translation start codon AUG. Precursor mRNA is posttranscriptionally modified by the removal of introns and by the addition at the 5′ end of a 7-methyl-guanylate cap structure, which has a crucial role in translation initiation and in regulating transcript stability. 5′-UTRs as well as 3′-UTRs, are deeply involved in regulation of gene expression through specific motifs that can affect mRNA stability, subcellular localization, nuclear export, tissue specificity and efficiency of translation.


  • translation initiation;
  • mRNA stability;
  • uAUG;
  • uORF;
  • internal ribosome entry site