5′-UTRs and Regulation
Published Online: 28 SEP 2007
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Mignone, F. and Pesole, G. 2007. 5′-UTRs and Regulation. eLS. .
- Published Online: 28 SEP 2007
The 5′ untranslated region consists of the leading part of a cellular messenger ribonucleic acid (mRNA) from the 5′ end to the translation start codon AUG. Precursor mRNA is posttranscriptionally modified by the removal of introns and by the addition at the 5′ end of a 7-methyl-guanylate cap structure, which has a crucial role in translation initiation and in regulating transcript stability. 5′-UTRs as well as 3′-UTRs, are deeply involved in regulation of gene expression through specific motifs that can affect mRNA stability, subcellular localization, nuclear export, tissue specificity and efficiency of translation.
- translation initiation;
- mRNA stability;
- internal ribosome entry site